Molecular chemotherapy of pancreatic cancer using novel mutant bacterial cytosine deaminase gene.

@article{Kaliberova2008MolecularCO,
  title={Molecular chemotherapy of pancreatic cancer using novel mutant bacterial cytosine deaminase gene.},
  author={Lyudmila N. Kaliberova and Debbie L Della Manna and Valentina Krendelchtchikova and Margaret E. Black and Donald J Buchsbaum and Sergey A. Kaliberov},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 9},
  pages={2845-54}
}
The combination of molecular chemotherapy with radiation therapy has the potential to become a powerful approach for treatment of pancreatic cancer. We have developed an adenoviral vector (AdbCD-D314A) encoding a mutant bacterial cytosine deaminase (bCD) gene, which converts the prodrug 5-fluorocytosine (5-FC) into the active drug 5-fluorouracil. The aim of… CONTINUE READING