Molecular characterization of volume-sensitive SK(Ca) channels in human liver cell lines.

@article{Roman2002MolecularCO,
  title={Molecular characterization of volume-sensitive SK(Ca) channels in human liver cell lines.},
  author={Richard M. Roman and Andrew P. Feranchak and Marlyn Troetsch and Jeffrey C Dunkelberg and Gordon Kilic and Thorsten Schlenker and Jerome Schaack and J. Gregory Fitz},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={282 1},
  pages={G116-22}
}
In human liver, Ca(2+)-dependent changes in membrane K(+) permeability play a central role in coordinating functional interactions between membrane transport, metabolism, and cell volume. On the basis of the observation that K(+) conductance is partially sensitive to the bee venom toxin apamin, we aimed to assess whether small-conductance Ca(2+)-sensitive K(+) (SK(Ca)) channels are expressed endogenously and contribute to volume-sensitive K(+) efflux and cell volume regulation. We isolated a… CONTINUE READING