Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters.

@article{Faaland1998MolecularCO,
  title={Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters.},
  author={C. A. Faaland and J. E. Race and G. Ricken and F. J. Warner and W. Williams and E. J. Holtzman},
  journal={Biochimica et biophysica acta},
  year={1998},
  volume={1442 2-3},
  pages={
          353-60
        }
}
  • C. A. Faaland, J. E. Race, +3 authors E. J. Holtzman
  • Published 1998
  • Biology, Medicine
  • Biochimica et biophysica acta
  • Nucleobase transport is important for the metabolism of nucleic acids and antiviral and antineoplastic drugs. This transport has been functionally described in several mammalian cells but has not been well characterized molecularly. We report the cloning of two novel transporters. YSPL2 encodes a 650-residue protein and has an ubiquitous 8 kb transcript. The human and pig homologs are 95% similar. YSPL3 encodes a 598-residue protein with a 3 kb transcript that is expressed only in kidney and… CONTINUE READING
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