Molecular characterization of two Arabidopsis Ire1 homologs, endoplasmic reticulum-located transmembrane protein kinases.

@article{Koizumi2001MolecularCO,
  title={Molecular characterization of two Arabidopsis Ire1 homologs, endoplasmic reticulum-located transmembrane protein kinases.},
  author={Nozomu Koizumi and Immaculada M. Martinez and Yusuke Kimata and Kenji Kohno and Hiroshi Sano and Maarten John Chrispeels},
  journal={Plant physiology},
  year={2001},
  volume={127 3},
  pages={949-62}
}
A major response of eukaryotic cells to the presence of unfolded proteins in the lumen of the endoplasmic reticulum (ER) is to activate genes that encode ER-located molecular chaperones, such as the binding protein. This response, called the unfolded protein response, requires the transduction of a signal from the ER to the nucleus. In yeast (Saccharomyces cerevisiae) and mammalian cells, an ER-located transmembrane receptor protein kinase/ribonuclease called Ire1, with a sensor domain in the… CONTINUE READING
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