Molecular characterization of the receptor binding structure-activity relationships of influenza B virus hemagglutinin.

@article{Carbone2013MolecularCO,
  title={Molecular characterization of the receptor binding structure-activity relationships of influenza B virus hemagglutinin.},
  author={V. Carbone and Hyun-Ju Kim and Johnny X. Huang and Matthew A Baker and C Ong and Matthew A. Cooper and Jie Li and Steven Rockman and Tony Velkov},
  journal={Acta virologica},
  year={2013},
  volume={57 3},
  pages={313-32}
}
Selectivity of α2,6-linked human-like receptors by B hemagglutinin (HA) is yet to be fully understood. This study integrates binding data with structure-recognition models to examine the impact of regional-specific sequence variations within the receptor-binding pocket on selectivity and structure activity relationships (SAR). The receptor-binding selectivity of influenza B HAs corresponding to either B/Victoria/2/1987 or the B/Yamagata/16/88 lineages was examined using surface plasmon… CONTINUE READING
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