Molecular characterization of the human common fragile site FRA1H

@article{Curatolo2007MolecularCO,
  title={Molecular characterization of the human common fragile site FRA1H},
  author={Angela Curatolo and Zaira M Limongi and Franca Pelliccia and Angela Rocchi},
  journal={Genes},
  year={2007},
  volume={46}
}
The molecular basis of the fragility of common fragile sites (CFS) and their role in chromosome instability and in altered expression of associated genes in cancer cells have not yet been clarified. In the present work we analyzed the human CFS FRA1H. FRA1H is the first characterized CFS the expression of which is not induced by aphidicolin but instead by DAPI. 5‐azaC, 5‐azadC, and Ad12 induce a CFS with the same cytogenetic location. By using FISH analysis with BAC clones, we determined that… 
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