Molecular characterization of the hemin uptake locus (hmu) from Yersinia pestis and analysis of hmu mutants for hemin and hemoprotein utilization.

@article{Thompson1999MolecularCO,
  title={Molecular characterization of the hemin uptake locus (hmu) from Yersinia pestis and analysis of hmu mutants for hemin and hemoprotein utilization.},
  author={Jan M Thompson and Heather A Jones and Robert D. Perry},
  journal={Infection and immunity},
  year={1999},
  volume={67 8},
  pages={3879-92}
}
Sequence analysis of the hemin uptake locus (hmu) of Yersinia pestis revealed five genes, hmuRSTUV, required for use of hemin and hemoproteins as iron sources. The translated gene products have homologies with proteins of the hemin transport genes of several gram-negative bacteria. Promoters were identified upstream of hmuP'R (p1) and upstream of hmuS (p2); p1, which contains a Fur box, is regulated by iron and Fur, while p2 exhibits weak, but constitutive, activity. HmuR, which has homology… CONTINUE READING

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References

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Showing 1-10 of 72 references

DNA sequence and expression of a Pseudomonas aeruginosa receptor and ABC transporter locus homologous to haemin iron uptake systems of bacterial pathogens

  • U. A. Ochsner, Z. Johnson, Z. Vasil, M. L. Vasil
  • abstr. B258,
  • 1998
2 Excerpts

Role of the Haemophilus ducreyi Ton system in internalization of heme from hemoglo

  • S. W. Bearden, R. D. Perry
  • Infect . Immun .
  • 1998

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