Molecular characterization of the gene for human interleukin-1 beta converting enzyme (IL1BC).

@article{Cerretti1994MolecularCO,
  title={Molecular characterization of the gene for human interleukin-1 beta converting enzyme (IL1BC).},
  author={Douglas Pat Cerretti and L T Hollingsworth and Carl J. Kozlosky and Marcus B. Valentine and David N. Shapiro and Stephan W. Morris and Nathan Alfred Nelson},
  journal={Genomics},
  year={1994},
  volume={20 3},
  pages={468-73}
}
Interleukin-1 beta (IL-1 beta) mediates a wide range of immune and inflammatory responses. The active cytokine is generated by proteolytic cleavage of an inactive precursor by a protease called the IL-1 beta converting enzyme (ICE). A cDNA encoding this protease was recently isolated. A human genomic clone containing the ICE gene (IL1BC) was isolated using the cDNA as a probe. The gene consists of 10 exons spanning at least 10.6 kb. 5'-anchored polymerase chain reaction indicated a single… CONTINUE READING