Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11.

@article{Peschke1995MolecularCO,
  title={Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11.},
  author={Ursula Peschke and Herbert Schmidt and Hua Zhong Zhang and W. Piepersberg},
  journal={Molecular microbiology},
  year={1995},
  volume={16 6},
  pages={1137-56}
}
The lincomycin (LM)-production gene cluster of the overproducing strain Streptomyces lincolnensis 78-11 was cloned, analysed by hybridization, as well as by DNA sequencing, and compared with the respective genome segments of other lincomycin producers. The lmb/lmr gene cluster is composed of 27 open reading frames with putative biosynthetic or regulatory functions (lmb genes) and three resistance (lmr) genes, two of which, lmrA and lmrC, flank the cluster. A very similar overall organization of… CONTINUE READING
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