Molecular characterization of the essential response regulator protein YycF in Bacillus subtilis.

@article{Watanabe2003MolecularCO,
  title={Molecular characterization of the essential response regulator protein YycF in Bacillus subtilis.},
  author={Takafumi Watanabe and Yoshiki Hadano-shi Hashimoto and Yoshihito Umemoto and Daisuke Tatebe and Eiji Furuta and Tamo Fukamizo and Kaneyoshi Yamamoto and Ryutaro Utsumi},
  journal={Journal of molecular microbiology and biotechnology},
  year={2003},
  volume={6 3-4},
  pages={
          155-63
        }
}
The response regulator YycF is essential for cell growth in gram-positive bacteria including Bacillus subtilis, Staphylococcus aureus and Streptococcus pneumoniae. To study the function of YycF in the essential process, we characterized a YycF (H215P) mutation that caused temperature-sensitive growth in B. subtilis. The response regulators YycF and YycF (H215P) were analyzed using circular dichroism spectroscopy, whose T(m) values were 56.0 and 45.9 degrees C, respectively, suggesting that YycF… CONTINUE READING
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