Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

@article{Montell1989MolecularCO,
  title={Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction},
  author={Craig Montell and Gerald M. Rubin},
  journal={Neuron},
  year={1989},
  volume={2},
  pages={1313-1323}
}
Recent studies suggest that the fly uses the inositol lipid signaling system for visual excitation and that the Drosophila transient receptor potential (trp) mutation disrupts this process subsequent to the production of IP3. In this paper, we show that trp encodes a novel 1275 amino acid protein with eight putative transmembrane segments. Immunolocalization indicates that the trp protein is expressed predominantly in the rhabdomeric membranes of the photoreceptor cells. 
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The TRP Channel and Phospholipase C-Mediated Signaling
  • B. Minke
  • Biology, Medicine
  • Cellular and Molecular Neurobiology
  • 2004
TLDR
Drosophila photoreceptors use a phospholipase C-mediated signaling for phototransduction and TRP protein is essential for the high Ca2+ permeability and constitutes the major component of the light-induced current, thereby affecting both excitation and adaptation of the photoreceptor cell. Expand
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