Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1.

  title={Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1.},
  author={C R McKeown and Hsiao-Fen Han and Mary C Beckerle},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={235 2},
Members of the ALP/Enigma family of PDZ-LIM proteins play a role in cytoskeletal anchorage and mutations in at least one member of this family are associated with human cardiomyopathy. Here, we describe the analysis of the Caenorhabditis elegans alp-1 gene. alp-1 is predicted to encode the entire nematode ALP/Enigma protein family, consisting of one ALP-related protein with a single LIM domain and three Enigma-like proteins containing four LIM domains. We demonstrate that the ALP-1 proteins are… CONTINUE READING

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