Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA.

@article{Jewett2011MolecularCO,
  title={Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA.},
  author={Mollie W Jewett and Sunny Jain and Angelika K. Linowski and Amit Sarkar and Patricia A Rosa},
  journal={Microbiology},
  year={2011},
  volume={157 Pt 10},
  pages={2831-40}
}
The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in maintaining NAD(+) homeostasis and contributes to numerous important biological processes in diverse organisms. In Borrelia burgdorferi, the nicotinamidase enzyme, PncA, is required for spirochaete survival throughout the infectious cycle. Mammals lack nicotinamidases and therefore PncA may serve as a therapeutic target for Lyme disease. Contrary to the in vivo importance of PncA, the current… CONTINUE READING