Molecular characterization of thalassemia intermedia in Indians.

@article{Panigrahi2006MolecularCO,
  title={Molecular characterization of thalassemia intermedia in Indians.},
  author={Inusha Panigrahi and Sarita Agarwal and Mandakini Pradhan and Dharma R. Choudhry and Ved Prakash Choudhry and Renu Sharma Raj Kumar Tanuja Srivastava D. C. Saxena},
  journal={Haematologica},
  year={2006},
  volume={91 9},
  pages={1279-80}
}
Thalassemia intermedia shows considerable heterogeneity. The purpose of this study was to evaluate the prevalence and effect of common molecular determinants in thalassemia intermedia. In 73 cases of thalassemia intermedia, the possible molecular basis was co-existent a-deletions (n=16/50), homozygous XmnI polymorphism (n=17/50), both factors (n=3/50), and milder beta-alleles (n=9/50) in homozygous beta-thalassemia (total 50 cases). In heterozygous beta-thalassemia, alphaalphaalphaanti-3.7… CONTINUE READING

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