Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation.

@article{Bozzi2008MolecularCO,
  title={Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation.},
  author={Fabio Bozzi and Andrea Ferrari and Tiziana Negri and Elena Conca and Da Riva Luca and Marco Losa and Paola Casieri and Marta Orsenigo and Andrea Lampis and Cristina Meazza and Michela Casanova and Marco Alessandro Pierotti and Elena Tamborini and Silvana Pilotti},
  journal={Translational oncology},
  year={2008},
  volume={1 2},
  pages={95-101}
}
Synovial sarcoma (SS) is the most frequent nonrhabdomyosarcomatous soft tissue sarcoma encountered in adolescents and young adults, and despite advances in the treatment of local disease, metastases remain the main cause of death. The aim of this study was to characterize a single-center series of pediatric SS molecularly to seek any biomarkers or pathways that might make suitable targets for new agents. Seventeen cases of pediatric SS showing the SYT-SSX fusion transcript were screened… CONTINUE READING
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