Molecular characterization of subgenotype A1 (subgroup Aa) of hepatitis B virus.

  title={Molecular characterization of subgenotype A1 (subgroup Aa) of hepatitis B virus.},
  author={Anna Kramvis and Michael Charles Kew},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  volume={37 s1},
Subgenotypes of hepatitis B virus (HBV) were first recognized after a unique segment of genotype A was identified when sequencing the preS2/S region of southern African HBV isolates. Originally named subgroup A', subsequently called subgroup Aa (for Africa) or subgenotype A1, this subgenotype is found in South Africa, Malawi, Uganda, Tanzania, Somalia, Yemen, India, Nepal, the Philippines and Brazil. The relatively higher mean nucleotide divergence of subgenotype A1 suggests that it has been… CONTINUE READING


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