Molecular characterization of ribonucleoproteic antigens containing repeated amino acid sequences from Trypanosoma cruzi.

@article{Pais2008MolecularCO,
  title={Molecular characterization of ribonucleoproteic antigens containing repeated amino acid sequences from Trypanosoma cruzi.},
  author={Fabiano Sviatopolk-Mirsky Pais and Wanderson Duarte Darocha and Ramon M Almeida and Sophie Yvette Leclercq and Marcus Luiz de Oliveira Penido and Stenio Perdig{\~a}o Fragoso and Daniella Castanheira Bartholomeu and Ricardo Tostes Gazzinelli and Santuza Maria Ribeiro Teixeira},
  journal={Microbes and infection},
  year={2008},
  volume={10 7},
  pages={716-25}
}
Trypanosoma cruzi expresses several proteins containing antigenic amino acid repeats. Here we characterized TcRpL7a and TcRBP28, which carry similar repeat motifs and share homology to the eukaryotic L7a ribosomal protein and to a Trypanosoma brucei RNA binding protein, respectively. Analyses of the full length and truncated recombinant TcRpL7a showed that the humoral response of patients with Chagas disease is directed towards its repetitive domain. Sequence analyses of distinct copies of… CONTINUE READING
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