Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

@inproceedings{Wang2012MolecularCO,
  title={Molecular characterization of proprotein convertase subtilisin/kexin type
9-mediated degradation of the LDLR},
  author={Yanli Wang and Yongcheng Huang and Helen H. Hobbs and Jonathan C. Cohen},
  booktitle={Journal of lipid research},
  year={2012}
}
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that promotes degradation of cell surface LDL receptors (LDLRs) in selected cell types. Here we used genetic and pharmacological inhibitors to define the pathways involved in PCSK9-mediated LDLR degradation. Inactivating mutations in autosomal recessive hypercholesterolemia (ARH), an endocytic adaptor, blocked PCSK9-mediated LDLR degradation in lymphocytes but not in fibroblasts. Thus, ARH is not specifically required… CONTINUE READING
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