Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef(I).

@article{Cochetti2005MolecularCO,
  title={Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef(I).},
  author={Ileana Cochetti and Manuela Vecchi and Marina Mingoia and Emily Tili and Maria Rosaria Catania and Aldo Manzin and Pietro Emanuele Varaldo and Maria Pia Montanari},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 12},
  pages={4999-5006}
}
The molecular genetics of macrolide resistance were analyzed in 49 clinical pneumococci (including an "atypical" bile-insoluble strain currently assigned to the new species Streptococcus pseudopneumoniae) with efflux-mediated erythromycin resistance (M phenotype). All test strains had the mef gene, identified as mef(A) in 30 isolates and mef(E) in 19 isolates (including the S. pseudopneumoniae strain) on the basis of PCR-restriction fragment length polymorphism analysis. Twenty-eight of the 30… CONTINUE READING

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