Molecular characterization of pharmacological properties and selectivity of SWR-0315NA for beta3-adrenoceptors.

@article{Ahmed2004MolecularCO,
  title={Molecular characterization of pharmacological properties and selectivity of SWR-0315NA for beta3-adrenoceptors.},
  author={Maruf Ahmed and Yoko Hanaoka and T. Kiso and T. Kakita and Y. Ohtsubo and T. Nagatomo},
  journal={Biological \& pharmaceutical bulletin},
  year={2004},
  volume={27 5},
  pages={
          718-22
        }
}
The pharmacological properties of SWR-0315NA, (E,Z)-[4[[1-[2-[(3-phenoxy-2-hydroxy propyl)]amino]ethyl]-1-propenyl]phenoxy]acetic acid sodium, were compared with those of (-)-isoproterenol. In the radioligand binding studies of [(125)I]iodocyanopindolol with COS-7 cell membranes that transiently expressed human beta-adrenoceptor (beta-AR) subtypes, SWR-0315NA exhibited 1-fold and 2-fold greater binding affinities for beta(3)-AR than those for beta(1)- and beta(2)-ARs, respectively. The maximal… Expand
Comparison of the binding affinity of some newly synthesized phenylethanolamine and phenoxypropanolamine compounds at recombinant human β‐ and α1‐adrenoceptor subtypes
TLDR
Six new compounds were evaluated and the binding affinities for human α1‐adrenoceptors expressed in Chinese hamster ovary (CHO) cells were compared using a radioligand‐binding assay to confirm the finding of this manuscript that this phenoxypropanolamine group of β2‐phenyl‐2‐hydroxyethyl ligands could also be used as α1-adrenOceptor ligands. Expand

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