Molecular characterization of pharmacological properties and selectivity of SWR-0315NA for beta3-adrenoceptors.

  title={Molecular characterization of pharmacological properties and selectivity of SWR-0315NA for beta3-adrenoceptors.},
  author={Maruf Ahmed and Yoko Hanaoka and T. Kiso and T. Kakita and Y. Ohtsubo and T. Nagatomo},
  journal={Biological \& pharmaceutical bulletin},
  volume={27 5},
The pharmacological properties of SWR-0315NA, (E,Z)-[4[[1-[2-[(3-phenoxy-2-hydroxy propyl)]amino]ethyl]-1-propenyl]phenoxy]acetic acid sodium, were compared with those of (-)-isoproterenol. In the radioligand binding studies of [(125)I]iodocyanopindolol with COS-7 cell membranes that transiently expressed human beta-adrenoceptor (beta-AR) subtypes, SWR-0315NA exhibited 1-fold and 2-fold greater binding affinities for beta(3)-AR than those for beta(1)- and beta(2)-ARs, respectively. The maximal… Expand
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