Molecular characterization of p16-immunopositive but HPV DNA-negative oropharyngeal carcinomas.

  title={Molecular characterization of p16-immunopositive but HPV DNA-negative oropharyngeal carcinomas.},
  author={M M Rietbergen and Peter J. F. Snijders and Derakshan Beekzada and Boudewijn J. M. Braakhuis and A. F. Ten Brink and Dani{\"e}lle A M Heideman and Albertus Theodorus Hesselink and Birgit I. Witte and Elisabeth Bloemena and Robert J Baatenburg-De Jong and C. Rene ¤ Leemans and Ruud H. Brakenhoff},
  journal={International journal of cancer},
  volume={134 10},
Recent studies have reported that p16 protein overexpression qualifies as a surrogate marker identifying an oncogenic human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC). However, there is still a percentage of OPSCCs that are positive for p16 immunohistochemistry (p16 IHC) but lack HPV DNA. The objective of this study was to characterize this group at the molecular level by performing sensitive HPV DNA- and RNA-based PCR methods and genetic profiling. All… CONTINUE READING
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