Molecular characterization of mitochondrial apoptosis-inducing factor

@article{Susin1999MolecularCO,
  title={Molecular characterization of mitochondrial apoptosis-inducing factor},
  author={S. Susin and H. Lorenzo and N. Zamzami and I. Marzo and B. Snow and G. Brothers and J. Mangion and {\'E}. Jacotot and P. Costantini and M. Loeffler and N. Larochette and D. Goodlett and R. Aebersold and D. Siderovski and J. Penninger and G. Kroemer},
  journal={Nature},
  year={1999},
  volume={397},
  pages={441-446}
}
Mitochondria play a key part in the regulation of apoptosis (cell death). Their intermembrane space contains several proteins that are liberated through the outer membrane in order to participate in the degradation phase of apoptosis. Here we report the identification and cloning of an apoptosis-inducing factor, AIF, which is sufficient to induce apoptosis of isolated nuclei. AIF is a flavoprotein of relative molecular mass 57,000 which shares homology with the bacterial oxidoreductases; it is… Expand
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