Molecular characterization of mitocalcin, a novel mitochondrial Ca2+-binding protein with EF-hand and coiled-coil domains.

@article{Tominaga2006MolecularCO,
  title={Molecular characterization of mitocalcin, a novel mitochondrial Ca2+-binding protein with EF-hand and coiled-coil domains.},
  author={Mitsutoshi Tominaga and Hidetake Kurihara and Shinya Honda and Genta Amakawa and Tatsuo Sakai and Yasuhiro Tomooka},
  journal={Journal of neurochemistry},
  year={2006},
  volume={96 1},
  pages={292-304}
}
Here we have identified and characterized a novel mitochondrial Ca2+-binding protein, mitocalcin. Western blot analysis demonstrated that mitocalcin was widely expressed in mouse tissues. The expression in brain was increased during post-natal to adult development. Further analyses were carried out in newly established neural cell lines. The protein was expressed specifically in neurons but not in glial cells. Double-labeling studies revealed that mitocalcin was colocalized with mitochondria in… CONTINUE READING

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