Molecular characterization of major histocompatibility complex class II alleles in wild tiger salamanders (Ambystoma tigrinum)

@article{Bos2005MolecularCO,
  title={Molecular characterization of major histocompatibility complex class II alleles in wild tiger salamanders (Ambystoma tigrinum)},
  author={D. H. Bos and J. A. DeWoody},
  journal={Immunogenetics},
  year={2005},
  volume={57},
  pages={775-781}
}
  • D. H. Bos, J. A. DeWoody
  • Published 2005
  • Biology, Medicine
  • Immunogenetics
  • Major histocompatibility complex (MHC) class II genes are usually among the most polymorphic in vertebrate genomes because of their critical role (antigen presentation) in immune response. Prior to this study, the MHC was poorly characterized in tiger salamanders (Ambystoma tigrinum), but the congeneric axolotl (Ambystoma mexicanum) is thought to have an unusual MHC. Most notably, axolotl class II genes lack allelic variation and possess a splice variant without a full peptide binding region… CONTINUE READING
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