Molecular characterization of human skin response to diphencyprone at peak and resolution phases: therapeutic insights

@inproceedings{Gulati2014MolecularCO,
  title={Molecular characterization of human skin response to diphencyprone at peak and resolution phases: therapeutic insights},
  author={Nicholas D Gulati and Mayte Su{\'a}rez-Fari{\~n}as and Judilyn Fuentes-Duculan and Patricia M Gilleaudeau and Mary M Sullivan-Whalen and Joel Maur{\'i}cio Correa da Rosa and Inna Cueto and Hiroshi Mitsui and James G. Krueger},
  booktitle={The Journal of investigative dermatology},
  year={2014}
}
Diphencyprone (DPCP) is a hapten that induces delayed-type hypersensitivity (DTH) reactions. It is used as an immune-modulating therapeutic, but its molecular effects in human skin are largely unknown. We studied cellular and molecular characteristics of a recall response to 0.04% DPCP at 3-day (peak) and 14-day (resolution) time points using immune markers, reverse-transcriptase-PCR (RT-PCR), and gene array approaches. A peak response showed modulation of ∼7,500 mRNA transcripts, with high… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
5 Citations
25 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Similar Papers

Loading similar papers…