Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction.

Abstract

UNLABELLED Melanocortin-3 receptor (MC3R), primarily expressed in the hypothalamus, plays an important role in the regulation of energy homeostasis. MC3R-deficient (MC3R(-)(/)(-)) mice demonstrate increased fat mass, higher feeding efficiency, hyperleptinaemia, and mild hyperinsulinism. At least one specific mutation of MC3R has been identified to be… (More)

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@article{Chen2006MolecularCO, title={Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction.}, author={Shigang Chen and Charles J. Aprahamian and Ahmet Çelik and Keith E. Georgeson and W Timothy Garvey and Carroll McWilliams Harmon and Yingkui Yang}, journal={Biochemistry}, year={2006}, volume={45 4}, pages={1128-37} }