Molecular characterization of flubendiamide sensitivity in the lepidopterous ryanodine receptor Ca(2+) release channel.

@article{Kato2009MolecularCO,
  title={Molecular characterization of flubendiamide sensitivity in the lepidopterous ryanodine receptor Ca(2+) release channel.},
  author={Kenta Kato and Shigeki Kiyonaka and Yuichi Sawaguchi and Masanori Tohnishi and Takao Masaki and Noriaki Yasokawa and Yusuke Mizuno and Emiko Mori and Keisuke Inoue and Itaru Hamachi and Hiroshi Takeshima and Yasuo Mori},
  journal={Biochemistry},
  year={2009},
  volume={48 43},
  pages={10342-52}
}
Flubendiamide is a benzenedicarboxamide derivative that shows selective insecticidal activity against lepidopterous insects. The specific modulatory effects of flubendiamide on ryanodine binding in insect muscle microsomal membranes suggest that the ryanodine receptor (RyR) Ca(2+) release channel is a primary target of flubendiamide. However, the molecular mechanisms underlying the species-specific action of flubendiamide are unclear. We have cloned cDNA encoding a novel RyR from the… CONTINUE READING