Molecular characterization of endothelin receptors.

@article{Sakurai1992MolecularCO,
  title={Molecular characterization of endothelin receptors.},
  author={Takeshi Sakurai and Masashi Yanagisawa and Tomoh Masaki},
  journal={Trends in pharmacological sciences},
  year={1992},
  volume={13 3},
  pages={103-8}
}
Following the first report on the identification of endothelin (ET), an increasing body of work has accumulated on this endothelium-derived 21-amino acid vasoconstrictor peptide. Subsequently, the existence of three distinct isoforms of ET, designated ET-1, ET-2 and ET-3, was predicted from the finding of three separate genes. The differential potencies of the three isoforms of the ET family have opened up the possibility of the existence of multiple ET receptor subtypes. Recently, molecular… CONTINUE READING