Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides.

@article{Fleckenstein2004MolecularCO,
  title={Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides.},
  author={Burkhard Fleckenstein and S W Qiao and Martin R Larsen and Guenther Jung and Peter Roepstorff and Ludvig M. Sollid},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 17},
  pages={17607-16}
}
Tissue transglutaminase (TG2) modifies proteins and peptides by transamidation or deamidation of specific glutamine residues. TG2 also has a central role in the pathogenesis of celiac disease. The enzyme is both the target of disease-specific autoantibodies and generates deamidated gliadin peptides recognized by intestinal T cells from patients. Incubation… CONTINUE READING