Molecular characterization of corona radiata cells from patients with diminished ovarian reserve using microarray and microfluidic-based gene expression profiling.

@article{MayPanloup2012MolecularCO,
  title={Molecular characterization of corona radiata cells from patients with diminished ovarian reserve using microarray and microfluidic-based gene expression profiling.},
  author={Pascale May-Panloup and V{\'e}ronique Ferr{\'e}-L'H{\^o}tellier and Catherine Morini{\`e}re and Charles Marcaillou and Sophie Lemerle and Myriam Malinge and Anne Coutolleau and Nicolas Lucas and Pascal Reynier and Philippe Descamps and Philippe Guardiola},
  journal={Human reproduction},
  year={2012},
  volume={27 3},
  pages={
          829-43
        }
}
BACKGROUND Diminished ovarian reserve (DOR) is one of the causes of infertility in young women. In this prospective study, gene expression profiling (GEP) of corona radiata cells (CRC) was performed to identify genes deregulated in DOR patients. METHODS Microarray-based GEP of CRC isolated from eight women undergoing IVF was performed to identify genes differentially expressed between patients with normal ovarian reserve and DOR patients. Microfluidic-based quantitative RT-PCR assays were… CONTINUE READING

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