Molecular characterization of an inward rectifier channel (IKir) found in avian vestibular hair cells: cloning and expression of pKir2.1.

@article{Correia2004MolecularCO,
  title={Molecular characterization of an inward rectifier channel (IKir) found in avian vestibular hair cells: cloning and expression of pKir2.1.},
  author={M. J. Correia and Thomas Wood and D. Prusak and Tianxiang Weng and Katherine Rennie and H Wang},
  journal={Physiological genomics},
  year={2004},
  volume={19 2},
  pages={155-69}
}
A fast inwardly rectifying current has been observed in some of the sensory cells (hair cells) of the inner ear of several species. While the current was presumed to be an IKir current, contradictory evidence existed as to whether the cloned channel actually belonged to the Kir2.0 subfamily of potassium inward rectifiers. In this paper, we report for the first time converging evidence from electrophysiological, biochemical, immunohistochemical, and genetic studies that show that the Kir2.1… CONTINUE READING