Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

  title={Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides},
  author={Benjamin F Cravatt and Dan K. Giang and Stephen Patrick Mayfield and Dale L. Boger and Richard Allen Lerner and Norton B. Gilula},
ENDOGENOUS neuromodulatory molecules are commonly coupled to specific metabolic enzymes to ensure rapid signal inactivation. Thus, acetylcholine is hydrolysed by acetylcholine esterase1 and tryptamine neurotransmitters like serotonin are degraded by monoamine oxidases2. Previously, we reported the structure and sleep-inducing properties of cis-9-octadecenamide, a lipid isolated from the cerebrospinal fluid of sleep-deprived cats3, cis-9-Octadecenamide, or oleamide, has since been shown to… CONTINUE READING
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