Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance.

Abstract

A clinical isolate of Serratia marcescens (TN9106) produced a metallo beta-lactamase (IMP-1) which conferred resistance to imipenem and broad-spectrum beta-lactams. The blaIMP gene providing imipenem resistance was cloned and expressed in Escherichia coli HB101. The IMP-1 was purified from E. coli HB101 that harbors pSMBNU24 carrying blaIMP, and its… (More)

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@article{Osano1994MolecularCO, title={Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance.}, author={E Osano and Y. Arakawa and R Wacharotayankun and M. Ohta and Takaaki Horii and H. Ito and Fumio Yoshimura and N. Kato}, journal={Antimicrobial agents and chemotherapy}, year={1994}, volume={38 1}, pages={71-8} }