Molecular characterization of an acidic phospholipase A2 from Bothrops pirajai snake venom: synthetic C-terminal peptide identifies its antiplatelet region

@article{Teixeira2011MolecularCO,
  title={Molecular characterization of an acidic phospholipase A2 from Bothrops pirajai snake venom: synthetic C-terminal peptide identifies its antiplatelet region},
  author={Sabrina Schaaf Teixeira and Lucas B. Silveira and Franco M. N. da Silva and Daniela P. Marchi-Salvador and Floriano P. Silva and Luiz Fernando M. Izidoro and Andr{\'e} Lopes Fuly and Maria Aparecida Juliano and Camila Ramos dos Santos and M{\'a}rio Tyago Murakami and Suely Vilela Sampaio and Saulo da Luz e Silva and Andreimar M. Soares},
  journal={Archives of Toxicology},
  year={2011},
  volume={85},
  pages={1219-1233}
}
This paper describes a biochemical and pharmacological characterization of BpirPLA2-I, the first acidic Asp49-PLA2 isolated from Bothrops pirajai. BpirPLA2-I caused hypotension in vivo, presented phospholipolytic activity upon artificial substrates and inhibitory effects on platelet aggregation in vitro. Moreover, a synthetic peptide of BpirPLA2-I, comprising residues of the C-terminal region, reproduced the antiplatelet activity of the intact protein. A cDNA fragment of 366 bp encompassing the… CONTINUE READING

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