Molecular characterization of an Italian series of sporadic GISTs

Abstract

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract. Most (80 %) contain activating mutations in the KIT receptor tyrosine kinase, roughly 10 % in platelet-derived growth factor receptor-alpha (PDGFRA). In a small subset, BRAF mutations are an alternative molecular pathway. GISTs respond well to imatinib, but low… (More)
DOI: 10.1007/s10120-012-0213-y

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@article{Origone2012MolecularCO, title={Molecular characterization of an Italian series of sporadic GISTs}, author={Paola Origone and Sara Gargiulo and L Mastracci and Alberto Ballestrero and L. Battistuzzi and Cinzia Casella and Danila Comandini and Roberto Cusano and Angelo Paolo dei Tos and R Fiocca and Anna Garuti and Paola Ghiorzo and Candela Martinuzzi and Luisa Toffolatti and Giovanna Bianchi Scarr{\`a}}, journal={Gastric Cancer}, year={2012}, volume={16}, pages={596-601} }