Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.

@article{Reppert1995MolecularCO,
  title={Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.},
  author={Steven M. Reppert and Catherine Godson and Cathy D. Mahle and David R Weaver and Susan A. Slaugenhaupt and James F. Gusella},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 19},
  pages={8734-8}
}
A G protein-coupled receptor for the pineal hormone melatonin was recently cloned from mammals and designated the Mel1a melatonin receptor. We now report the cloning of a second G protein-coupled melatonin receptor from humans and designate it the Mel1b melatonin receptor. The Mel1b receptor cDNA encodes a protein of 362 amino acids that is 60% identical at the amino acid level to the human Mel1a receptor. Transient expression of the Mel1b receptor in COS-1 cells results in high-affinity 2… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 23 references

Endocrinology

D R Nussenzveig, S Mathew, M D Gershengorn
Endocrinology • 1995

J. Biol. Chem

J Guiramand, J.-P Montmayeur, J Ceraline, M Bhatia, E Borrelli
J. Biol. Chem • 1995

Proc. Natl. Acad. Sci. USA 92

Proc. Natl. Acad. Sci. USA 92 • 1995

Neuron

S M Reppert, D R Weaver, T Ebisawa
Neuron • 1994

Proc. Natl. Acad. Sci. USA 91

R Ebisawa, S Karne, M R Lerner, S M Reppert
Proc. Natl. Acad. Sci. USA 91 • 1994

Alcohol

M R Kelly, J K Jurgens, +3 authors M A Emanuele
Alcohol • 1993

Genomics

T M Wilkie, Y Chen, +5 authors N A Jenkins
Genomics • 1993

Nucleic Acids Res

A S Goldsborough, L E Healy, +4 authors A Ashworth
Nucleic Acids Res • 1993

Cell. Mol. Neurobiol

G M Cahill, M S Grace, J C Besharse
Cell. Mol. Neurobiol • 1991

Endocr. Rev

R J Reiter
Endocr. Rev • 1991

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