Molecular characterization of a possible progenitor sodium channel toxin from the Old World scorpion Mesobuthus martensii.

@article{Zhu2006MolecularCO,
  title={Molecular characterization of a possible progenitor sodium channel toxin from the Old World scorpion Mesobuthus martensii.},
  author={Shunyi Zhu and Bo Gao},
  journal={FEBS letters},
  year={2006},
  volume={580 25},
  pages={5979-87}
}
Toxins affecting sodium channels widely exist in the venoms of scorpions throughout the world. These molecules comprise an evolutionarily related peptide family with three shared features including conserved three-dimensional structure and gene organization, and similar function. Based on different pharmacological profiles and binding properties, scorpion sodium channel toxins are divided into alpha- and beta-groups. However, their evolutionary relationship is not yet established. Here, we… CONTINUE READING

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