Molecular characterization of a peripheral receptor for cannabinoids

  title={Molecular characterization of a peripheral receptor for cannabinoids},
  author={Sean Munro and Kerrie L. Thomas and Muna Abu-Shaar},
THE major active ingredient of marijuana, Δ9-tetrahydrocannabi-nol (Δ9-THC), has been used as a psychoactive agent for thousands of years. Marijuana, and Δ9-THC, also exert a wide range of other effects including analgesia, anti-inflammation, immunosuppression, anticonvulsion, alleviation of intraocular pressure in glaucoma, and attenuation of vomiting1. The clinical application of cannabinoids has, however, been limited by their psychoactive effects, and this has led to interest in the… 
A molecular basis of the therapeutic and psychoactive properties of cannabis (Δ9-tetrahydrocannabinol)
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This data indicates that cannabinoid ligands may be effective agents in the treatment of chronic pain, glaucoma, spasms, and the wasting and emesis associated with acquired immunodeficiency syndrome and cancer chemotherapy through the mechanism by which they inhibit the growth of transformed cells.
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Structure of a cannabinoid receptor and functional expression of the cloned cDNA
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The potencies of a series of natural and synthetic cannabinoids as competitors of [3H]CP 55,940 binding correlated closely with their relative potencies in several biological assays, suggesting that the receptor characterized in the in vitro assay is the same receptor that mediates behavioral and pharmacological effects of cannabinoids, including human subjective experience.
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Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which has
Tetrahydrocannabinol‐Induced Suppression of Macrophage Spreading and Phagocytic Activity In Vitro
Results indicate that several readily measured functions of macrophages may be suppressed by cannabinoids, and higher doses of THC were necessary to inhibit phagocytosis of yeast particles.