Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.

@article{Abe1992MolecularCO,
  title={Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.},
  author={Tatsuo Abe and Hideki Sugihara and Hiroyuki Nawa and Ryuichi Shigemoto and Nobuyuki Mizuno and Shigetada Nakanishi},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 19},
  pages={
          13361-8
        }
}
A cDNA clone for a new metabotropic glutamate receptor, mGluR5, was isolated through polymerase chain reaction-mediated DNA amplification by using primer sequences conserved among the metabotropic glutamate receptor (mGluR) family and by the subsequent screening of a rat brain cDNA library. The cloned receptor consists of 1171 amino acid residues and exhibits a structural architecture common to the mGluR family, possessing a large extracellular domain preceding the seven putative membrane… CONTINUE READING

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