Molecular characterization of a novel human endothelin receptor splice variant.

@article{Elshourbagy1996MolecularCO,
  title={Molecular characterization of a novel human endothelin receptor splice variant.},
  author={Nabil A. Elshourbagy and John E. Adamou and Alison Williams Gagnon and Hsin Lung Wu and Jessica Pullen and P. Azhahia Nambi},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 41},
  pages={
          25300-7
        }
}
Endothelin receptors are widely distributed throughout a number of tissues. A novel ETB receptor splice variant (ETB-SVR) was identified from a human placental cDNA library. Sequence analysis indicated that the ETB-SVR is 436 amino acids long and shares 91% identity to the human ETB-R. Northern blot analysis indicated an mRNA species of 2.7 kilobases, which is expressed in the lung, placenta, kidney, and skeletal muscle. Ligand binding studies of the cloned ETB-SVR and ETB-R receptors expressed… CONTINUE READING
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