Molecular characterization of a new urea transporter in the human kidney.

@article{Olivs1996MolecularCO,
  title={Molecular characterization of a new urea transporter in the human kidney.},
  author={B Oliv{\`e}s and Sonia Martial and M. G. Matt{\'e}i and Giorgio Matassi and Germain Rousselet and Pierre Ripoche and J. P. Cartron and Pascal Bailly},
  journal={FEBS letters},
  year={1996},
  volume={386 2-3},
  pages={156-60}
}
A cDNA clone (HUT2) sharing 61.1% and 89.9% sequence identity with the human erythroid (HUT11) and the rabbit (UT2) urea transporters, respectively, was isolated by homology cloning from a human kidney library. HUT2 transcripts were restricted to the kidney and the HUT2 polypeptide was not immunoprecipitated with blood group Kidd-related antibodies (anti-Jk3) in coupled transcription-translation assays. Functional expression studies in Xenopus oocytes demonstrated that HUT2-mediated urea… CONTINUE READING