Molecular characterization of a duck Tembusu virus from China

Abstract

A new emerging flavivirus caused severe egg-drop in poultry and spread quickly across most duck-producing regions of China in 2010. Complete genome sequencing indicated that the virus genome is 10,989 nucleotides in length and possesses typical flavivirus genome organization, 5′ untranslated region (UTR)-Cv-Ci-prM-M-E-NS1-NS2A-NS2B-NS3-NS4A-2K-NS4B-NS5-3′-UTR. The long open reading frame (ORF) encodes 3,425 amino acids (95–10,372 nt). The 94-nucleotide 5′-UTR is of intermediate size and the 617-nucleotide 3′-UTR is quite long relative to those of other flaviviruses. The polyprotein cleavage sites, potential glycosylation sites, distribution of cysteine residues, and 3′-UTR secondary structure were characterized. Phylogenetic analysis of the polyprotein sequences indicates that the HN isolate is closely related to Tembusu viruses of the Ntaya virus group.

DOI: 10.1007/s11262-013-0966-3

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@article{Bai2013MolecularCO, title={Molecular characterization of a duck Tembusu virus from China}, author={Xiaofei Bai and Rang Lv and Chunguo Liu and Na Qiu and Yilong He and Xiuchen Yin and Xiaojun Li and Ming Liu and Yun Zhang}, journal={Virus Genes}, year={2013}, volume={47}, pages={478-482} }