Molecular characterization of a cloned human oxytocin receptor.

  title={Molecular characterization of a cloned human oxytocin receptor.},
  author={Tadashi Kimura and Y Makino and Fumitaka Saji and Masahiko Takemura and Tae Inoue and Tetsuro Kikuchi and Yoshiko Kubota and Chihiro Azuma and T Nobunaga and Yoshihiro Tokugawa},
  journal={European journal of endocrinology},
  volume={131 4},
We describe here the binding and functional properties of a cloned human oxytocin receptor (OTR). We established a transient OTR expression system on COS-1 cells, which do not express vasopressin receptors. With the transfected cells and [3H]oxytocin, the dissociation constant (Kd) of OTR to oxytocin was 6.0 +/- 1.1 nmol/l; the binding properties of several oxytocin-related peptides were also examined. The functional properties of OTR were determined by an electrophysiological method, using a… CONTINUE READING

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