Molecular characterization of Trimeresurus stejnegeri venom L-amino acid oxidase with potential anti-HIV activity.

@article{Zhang2003MolecularCO,
  title={Molecular characterization of Trimeresurus stejnegeri venom L-amino acid oxidase with potential anti-HIV activity.},
  author={Y Philip Zhang and Jianhua Wang and Wen-Hui Lee and Qian Wang and Heng Liu and Yong-Tang Zheng and Yun Zhi Zhang},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={309 3},
  pages={598-604}
}
A novel L-amino acid oxidase, named TSV-LAO, has been purified and cloned from the snake Trimeresurus stejnegeri. Fifty percentage cytotoxic concentrations (CC50) of TSV-LAO on C8166 cells were 24 and 390 nM in the absence or presence of catalase (400 nM), respectively. However, at concentrations that showed little effect on cell viability, TSV-LAO displayed dose dependent inhibition on HIV-1 infection and replication. The antiviral selectivity indexes (CC50/EC50) were 16 and 6, respectively… CONTINUE READING
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