Molecular characterization of TMPRSS2-ERG gene fusion in the NCI-H660 prostate cancer cell line: a new perspective for an old model.

@article{Mertz2007MolecularCO,
  title={Molecular characterization of TMPRSS2-ERG gene fusion in the NCI-H660 prostate cancer cell line: a new perspective for an old model.},
  author={Kirsten D. Mertz and Sunita R. Setlur and Saravana M. Dhanasekaran and Francesca Demichelis and Sven Perner and Scott Arthur Tomlins and Jo{\"e}lle Tchinda and Bharathi Laxman and Robert L. Vessella and Rameen Beroukhim and Charles Lee and Arul M. Chinnaiyan and Mark A. Rubin},
  journal={Neoplasia},
  year={2007},
  volume={9 3},
  pages={200-6}
}
Recent studies have established that a significant fraction of prostate cancers harbor a signature gene fusion between the 5' region of androgen-regulated TMPRSS2 and an ETS family transcription factor, most commonly ERG. Studies on the molecular mechanisms and functional consequences of this important chromosomal rearrangement are currently limited to the VCaP cell line derived from a vertebral bone metastasis of a hormone-refractory prostate tumor. Here we report on the NCI-H660 cell line… CONTINUE READING
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