• Corpus ID: 17660232

Molecular characterization of Streptococcus pneumoniae serotype 1 invasive isolates in Colombia.

  title={Molecular characterization of Streptococcus pneumoniae serotype 1 invasive isolates in Colombia.},
  author={Carolina Duarte and Olga Sanabria and Jaime Moreno},
  journal={Revista panamericana de salud publica = Pan American journal of public health},
  volume={33 6},
OBJECTIVE To determine the genetic relationship between Streptococcus pneumoniae serotype 1 Colombian isolates recovered from invasive disease between 1994 and 2011 and recognized serotype 1 international clones. METHODS A total of 135 S. pneumoniae serotype 1 isolates with epidemiological and antimicrobial susceptibility data (Clinical and Laboratory Standards Institute, 2012) were studied. The genetic relationship with recognized international clones was established by pulsed-field gel… 

Figures from this paper

Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity

Interestingly, the 2 strains did not differ in their ability to bind the immune complement or to undergo neutrophil-mediated phagocytosis, and it was found that ZmpA, ZmpD proteins, and IgA protease, were uniquely found in ST615.

Antimicrobial resistance in Streptococcus pneumoniae: mechanisms and current epidemiology

Although different clones of PNSP are internationally distributed, and considering diseases other than meningitis, the prevalence to penicillin is quite low, making this old, safe and inexpensive drug an attractive first choice to treat pneumococcal infections.

The Impact of Pneumolysin on the Macrophage Response to Streptococcus pneumoniae is Strain-Dependent

The impact of Ply on the immune response to the pneumococcus is highly dependent on the strain background, thus emphasising the importance of the interaction between specific virulence factors and other components of the genetic background of this organism.

Invasive pneumococcal disease burden in hospitalized adults in Bogota, Colombia

Assessment of Spn serotype distribution, clinical characteristics, mortality, ICU admission, and the need for mechanical ventilation in adults hospitalized due to IPD in Colombia found pneumonia is the most prevalent cause, with serotypes 19A and 3 being the leading cause in Colombian adults.

Comparative Genomic Analysis and In Vivo Modeling of Streptococcus pneumoniae ST3081 and ST618 Isolates Reveal Key Genetic and Phenotypic Differences Contributing to Clonal Replacement of Serotype 1 in The Gambia

Important evidence is provided to show that changes in the epidemiology of pneumococcal serotype 1 sequence types in The Gambia may be a direct consequence of differences in virulence and increased ability to colonize hosts over time.

Visualizing variation within Global Pneumococcal Sequence Clusters (GPSCs) and country population snapshots to contextualize pneumococcal isolates

This work prepared 12 country-specific phylogenetic snapshots, and international phylogenetic snapshot of 73 common Global Pneumococcal Sequence Clusters previously defined using PopPUNK, and presents them in Microreact, to increase dissemination of genomic insights to the wider community, without the need for specialist training.

Pneumococcal Burden in Hospitalized Adults in Bogotá, Colombia. 

Pneumococcal pneumonia is the most prevalent cause of IPD, with serotypes 19A and 3 being the leading cause in Colombian adults, and Mortality due to IPD in adults continues to be very high.



Presence of international multiresistant clones of Streptococcus pneumoniae in Colombia.

Results show that as many as two international clones may be circulating in Colombia as well as a unique, widely distributed 23F clone with ILR to penicillin and TMP-SMX, features unique to a Colombian clone.

Molecular assessment of invasive Streptococcus pneumoniae serotype 1 in Brazil: evidence of clonal replacement.

A temporal switch between two lineages of S. pneumoniae serotype 1 in Brazil is established, with a wide dispersion of clone Sweden(1)-40 in recent years.

A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease.

A pneumococcal multilocus sequence typing scheme and database is developed by sequencing approximately 450 bp fragments of seven housekeeping loci from 295 isolates to provide an allelic profile, or sequence type (ST), and the relatedness between isolates was obtained by constructing a dendrogram from the matrix of pairwise differences between STs.

Assessment of molecular typing methods to determine invasiveness and to differentiate clones of Streptococcus pneumoniae.

Dissemination of a Chloramphenicol- and Tetracycline-Resistant but Penicillin-Susceptible Invasive Clone of Serotype 5 Streptococcus pneumoniae in Colombia

Serotype 5 Streptococcus pneumoniae isolates collected during a national surveillance conducted in Colombia between 1994 and 1996 were shown to be susceptible to penicillin, erythromycin, cefotaxime, and vancomycin, but most (38 of 43, or 88%) were highly resistant to chloramphenicol.

Dissemination of Streptococcus pneumoniae Clone Colombia5-19 in Latin America

The S. pneumoniae serotype 5 isolates from Latin American are genetically closely related but show different patterns of antibiotic resistance, probably as a result of horizontal transfer.

Geographic Distribution and Clonal Diversity of Streptococcus pneumoniae Serotype 1 Isolates

Serotype 1 pneumococci are a major cause of serious disease and have been associated with outbreaks but are rarely carried, and clustered into three major lineages with very different geographic distributions.

Clonal structure and 21-year evolution of Streptococcus pneumoniae serotype 1 isolates in northern Spain.

This study of 135 serotype 1 pneumococcal isolates, collected between 1987 and 2007, gave eight sequence types that group, using eBurst, into three different lineages and one singleton that was the predominant clone until 1998 and became the most prevalent sequence type after the introduction of the heptavalent pneumitiscal conjugate vaccine.

Multi-Virulence-Locus Sequence Typing of Listeria monocytogenes

MVLST may improve the discriminatory power of MLST and provide a convenient tool for studying the local epidemiology of L. monocytogenes, according to the published results of other typing methods.

Laboratory-Based Surveillance of Streptococcus pneumoniae Invasive Disease in Children in 10 Latin American Countries: A SIREVA II Project, 2000–2005

Although 61 different capsular types were identified during the 6-year surveillance, 13 serotypes accounted for 86% of all isolates and these were consistently the most prevalent throughout the study period with serotype 14 predominating.