Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.

@article{Poynter2008MolecularCO,
  title={Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.},
  author={Jenny N. Poynter and Kimberly D. Siegmund and Daniel J. Weisenberger and Tiffany I. Long and Stephen N. Thibodeau and Noralane M. Lindor and Joanne P. Young and Mark A Jenkins and John L. Hopper and John A. Baron and Dan D. Buchanan and Graham R Casey and Andrew J. Levine and Lo{\"i}c Le Marchand and Steven Gallinger and Bharati Bapat and John D. Potter and Polly A Newcomb and Robert W Haile and Peter W. Laird},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2008},
  volume={17 11},
  pages={3208-15}
}
Microsatellite instability (MSI) occurs in 10% to 20% of colorectal cancers (CRC) and has been attributed to both MLH1 promoter hypermethylation and germline mutation in the mismatch repair (MMR) genes. We present results from a large population- and clinic-based study of MLH1 methylation, immunohistochemistry, and MMR germline mutations that enabled us to (a) estimate the prevalence of MMR germline mutations and MLH1 methylation among MSI-H cases and help us understand if all MSI-H CRC is… CONTINUE READING
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Molecular Characterization of MSI-H CRC Cancer Epidemiol Biomarkers Prev 2008;17(11)

  • M Yearsley, H Hampel, A Lehman, H Nakagawa, A de la Chapelle
  • Research. on March
  • 2008
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