Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

@article{Martinez2015MolecularCO,
  title={Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins},
  author={Jennifer Martinez and R K Subbarao Malireddi and Qun Lu and Larissa Dias Cunha and Stephane Pelletier and S{\'e}bastien Gingras and Robert Orchard and Jun-Lin Guan and Haiyan Tan and Junmin Peng and Thirumala-Devi Kanneganti and Herbert W Virgin and Douglas R Green},
  journal={Nature Cell Biology},
  year={2015},
  volume={17},
  pages={893-906}
}
LC3-associated phagocytosis (LAP) is a process wherein elements of autophagy conjugate LC3 to phagosomal membranes. We characterize the molecular requirements for LAP, and identify Rubicon as being required for LAP but not autophagy. Rubicon is recruited to LAPosomes and is required for the activity of a Class III PI(3)K complex containing UVRAG but lacking ATG14 and Ambra1. This allows for the sustained localization of PtdIns(3)P, which is critical for recruitment of downstream autophagic… CONTINUE READING
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