Molecular characterization of HIV type 1 isolates from untreated patients of Mumbai (Bombay), India, and detection of rare resistance mutations.

@article{Deshpande2004MolecularCO,
  title={Molecular characterization of HIV type 1 isolates from untreated patients of Mumbai (Bombay), India, and detection of rare resistance mutations.},
  author={Alaka K. Deshpande and Patricia Recordon-Pinson and Ranjana A. Deshmukh and Muriel Faure and Val{\'e}rie Jauvin and Isabelle Garrigue and Marie-Edith Lafon and H{\'e}rv{\'e} Fleury},
  journal={AIDS research and human retroviruses},
  year={2004},
  volume={20 9},
  pages={1032-5}
}
The molecular characterization of HIV-1 isolates in drug-naive cases in the early stages of HIV disease was studied in 128 cases from Mumbai (Bombay), India. Subtype C was largely predominant followed by A-C intersubtype recombinants, one subtype A and one CRF01 AE. Compared to subtype B, subtype C exhibited an important polymorphism; the percentages of substitutions could reach more than 90%. Two isolates showed M184V substitution the reverse transcriptase indicating resistance to 3TC. 

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