Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells.

Abstract

The common fragile site, FRA3B, has been shown to be a site of frequent homozygous deletions in some cancers, resulting in loss of expression of the associated FHIT gene. It has been proposed that FHIT is a tumor suppressor gene that is inactivated as a result of the instability of FRA3B in tumorigenesis. More recently, deletions at other common fragile… (More)

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Cite this paper

@article{Arlt2002MolecularCO, title={Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells.}, author={Martin F Arlt and Diane E. Miller and David G Beer and Thomas W. Glover}, journal={Genes, chromosomes & cancer}, year={2002}, volume={33 1}, pages={82-92} }